By L. F. Gram, L. P. Balant, Herbert Y. Meltzer, S. G. Dahl
This publication includes the papers from invited academics in addition to chosen contributions awarded on the sixth foreign assembly on scientific Pharmacology in Psychiatry (I.M.C.P.P.) held in Geneva, Switzerland, 5-7 June 1991. At this assembly the elemental subject matter of the former conferences during this sequence (Chicago 1979, Troms0 1980, Odense 1982, Bethesda 1985, Troms0 1988) was once endured, particularly, to bridge the distance among experimental improvement and scientific fact in psychopharmacology. After greater than 25 years of extensive study in organic psychiatry, simple realizing of the organic mechanisms underlying significant psychiatric illnesses has complex considerably yet remains to be faraway from entire. Likewise, the hypotheses underlying the improvement of recent psychotropics were subtle and produced a large spectrum of novel, but designed compounds. The the most important for all growth during this box is trustworthy, informative scientific checking out of latest compounds. it's our wish that this publication, as a continuation of the sooner courses during this sequence, presents extra facts of the continuing interplay among preclinical and medical scientists, who purely jointly can guarantee development during this interesting quarter of analysis and scientific practice.
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While much has been learned from molecular biologic approaches about the structure of receptor SUbtypes, we are just entering the era in which these same strategies are being used to unravel the complexities of receptor regulation. How receptors are controlled - at all levels, from gene transcription to positive and negative feedback mechanisms regulating their response to changes in their synaptic milieu - will probably lead to new targets for selective drug action, representing many, if not all, the steps in the signal transduction cascade.
However, it should be emphasized that experiments on synaptosomes have not yet been carried out and that, hence, the location of this receptor on the 5-HT nerve terminal has not yet been proven. 3 Potential Role of Somadendritic 5·HT Autoreceptors in the Anxiolytic and Antidepressant Effect of Mixed FulllPartiai 5·HT lA Receptor Agonists The attempt to develop new anxiolytic drugs interacting with the serotoninergic system in the brain was based on the observation that, besides GABA, 5-HT is crucially involved in the effects of benzodiazepines (Koe 1979).
The fact that many new receptor subtypes are being discovered by gene cloning in every receptor family means that many new agents for manipulation of brain processes should soon become available. Many of these new ligands should prove to be more potent therapeutic agents with fewer side effects, due to their improved human receptor specificities. If this promise is realized, a second renaissance in neuropsychiatric drug design (following the great advances of the 1960s) could well be near at hand.