Ciba Foundation Symposium 141 - Metastasis by CIBA Foundation Symposium

By CIBA Foundation Symposium

A global crew of researchers addresses simple mechanism curious about the metastatic unfold of tumors and considers new tools of prevention and remedy. Compares habit of standard and irregular cells, with emphasis on mobilephone floor mechanisms--especially invasive processes--and inhibitors that will hinder metastasis. additionally discusses decision of the metastatic genotype, the position of the immune process, and relief of metastasis through liposome-activated macrophages.

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1 yg/ml) and the indicated additions. At 8, 24, 48 and 72 hours, 50 yl aliquots of the culture supernatants were removed and counted for 35S radioactivity. The 48-hour results are presented. NPGB, p-nitrophenyl guanidino benzoate. incubated for 4-7 days. On Day 14-17 the egg is opened, the tumour on the CAM is removed and weighed, and the lungs of the embryo are removed and finely minced and then passaged on to the CAMs of a second group of embryos. These embryos are incubated for 5-7 days to allow expansion of any HEp-3 cells present in the original lungs, and then the lung tumours on the second CAMs are assayed for HEp-3 cells both morphologically (lung tumour score) and by measurement of human plasminogen activator (PA,) activity (mU/mg lung protein).

That could be checked by using a spectrum of protease inhibitors, t o identify the other enzyme(s). Quigley: W e have done those experiments. After inhibiting matrix degradation with anti-PA and 1,IO-phenanthroline, the remaining 1&15% of degradative activity (Table 1, p 29) can be inhibited by thiol proteinase inhibitors, so there are a t least three enzymes operating here-PA, a metalloprotease, and a thiol protease. Roos: Transformation-induced alterations in chick embryo fibroblasts have been ascribed to changes in the cytoskeleton and adhesion plaques.

It is one that could be used to much greater effect to identify differences between metastatic and non-metastatic cell lines. Kerbel: Can D r Quigley tell us how his antibody and the antigen that it recognizes compares with what has been published by Dr Kimura? Quigley: I am not familiar with that work; Paul Patterson, a developmental neurobiologist, has been working o n this technique, to distinguish different embryonic stages, and it was through his work that I learned of the technique. But your point is well taken.

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