By Asim K. Duttaroy, Friedrich Spener
In mild of the expanding value of those proteins and their ligands for our realizing of mobile progress, differentiation, and improvement, in addition to of ailments similar to weight problems, insulin resistance, atherosclerosis, melanoma, and irritation, a staff of the world over popular editors and authors have compiled the following the first actual accomplished booklet on those subject matters. They describe fatty acid-activated transcription components in addition to membrane and soluble fatty acid transporters, overlaying such points as constitution and serve as, lipid-protein interplay, supply of ligands, and the jobs of those proteins in gene expression bearing on the homeostatic and diseased states of cells and organs.Incorporating fresh findings, this can be critical for uncomplicated scientists, overall healthiness execs in and clinics in addition to postgraduate students.Contributors between others: N.A. Abumrad, J.E. Schaffer, G. Schmitz, N.J. Brunskill, J. Storch, U. Seedorf, S. Mandrup, C.N.A. Palmer, T. Perlmann, H.I. Nebb, J. Bar-Tana, H. Kondo, C. Wolfrum, C. Kerkhoff , S. Farmer, E.J. Murphy, J.F.C. Glatz, P. Besnard, J.M. Stewart, A. Meirhaeghe, J. Plutzky, W. Wahli, R.A. Roberts
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L. Silverstein, J. Biol. Chem. 1998, 273, 34875– 34881. L. L. Leung, W. X. Li, J. L. McGregor, G. Albrecht, R. J. Howard, J. Biol. Chem. 1992, 267, 18244–18250. A. G. Baillie, C. T. Coburn, N. A. Abumrad, J. Membr. Biol. 1996, 153, 75–81. D. A. Brown, E. London, J. Biol. Chem. 2000, 275, 17221–17224. M. M. Huang, J. B. Bolen, J. W. Barnwell, S. J. Shattil, J. S. Brugge, Proc. Natl Acad. Sci. USA 1991, 88, 7844–7848. 25 26 1 Structure-Function of CD36 and Evidence for its Role in Facilitating Membrane Fatty Acid Transport 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 H.
This vicious cycle continues, escalating the hypoglycemia and dyslipidemia, as the fast progresses and is only partially compensated for by the rising ketone levels. by a FA-induced clamping of hepatic glucose output. Although this model is likely to be amended as more data are obtained, it nevertheless illustrates the important regulatory role of CD36 in the homeostatic mechanisms controlling both substrate transfer between tissues and the balance of local substrate utilization. 6 CD36 and Insulin Responsiveness in the Mouse As already noted, deficiency of FAT/CD36 has been genetically linked to insulin resistance in the SHR.
B. Podolsak, Thromb. Haemost. 1977, 37, 396–406. D. E. Greenwalt, N. N. Tandon, G. A. Jamieson, Thromb. Haemost. 1991, 65, 1153. A. S. Asch, I. Liu, F. M. Briccetti, J. W. Barnwell, F. Kwakye-Berko, A. Dokun, J. Goldberger, M. Pernambuco, Science 1993, 262, 1436–1440. M. Hatmi, J. M. Gavaret, I. Elalamy, B. B. Vargaftig, C. Jacquemin, J. Biol. Chem. 1996, 271, 24776–24780. L. Daviet, R. Buckland, M. D. Puente Navazo, J. L. McGregor, Biochem. J. 1995, 305, 221–224. A. S. Asch, J. Barnwell, R. L.