By Clifford P Stanners
Considers the hot explosion of data in regards to the carcinoembryonic antigen (CEA) family members, which resulted from the molecular cloning of loved one genes in 1986.
Results indicating CEA relations upregulated in melanoma can have an instrumental function in malignant transformation and metastasis, whereas those who are downregulated can have tumor suppressive services are thought of. stories, fresh effects, hypotheses, and scientific purposes concerning a gene relations that, from its common adjustments in expression in tumors at many websites, may be considered as a "major participant" in human melanoma also are mentioned. the conventional features reminiscent of epithelial and hematopoietic adhesion and signalling molecules are explored, and the doubtless particular position of this kin in evolution is brought.
This quantity might be of curiosity to researchers within the fields of intercellular adhesion, evolution, and molecular attractiveness, in addition to clinicians drawn to the new wisdom relating to a tumor marker regularly utilised within the health facility, and firms wishing to take advantage of this cancer-related relations for novel advertisement purposes within the biomedical sphere.
Read or Download Cell adhesion and communication mediated by the CEA family : basic and clinical perspectives PDF
Best cell biology books
The significantly acclaimed laboratory general, equipment in Enzymology , is among the such a lot hugely revered guides within the box of biochemistry. given that 1955, every one quantity has been eagerly awaited, usually consulted, and praised through researchers and reviewers alike. The sequence includes a lot fabric nonetheless correct at the present time - really a vital book for researchers in all fields of existence sciences.
Liposomes are mobile buildings made of lipid molecules. very important as a mobile version within the research of easy biology, liposomes also are utilized in scientific functions comparable to drug supply and virus stories. Liposomes half D is a continuation of past MIE Liposome volumes A, B, and C. Contents: Antibody or Ligand exact Liposomes; setting delicate liposomes; liposomal oligonucleotides; liposomes in vivo
This booklet brings jointly the foremost recommendations utilized in the isolation or enrichment of person populations of organelles and different subcellular buildings from crops with the objective that, by way of with the ability to isolate subcellular buildings, the learn and figuring out of assorted aspects of compartmentalized functionality in plant cells may be complicated.
Additional resources for Cell adhesion and communication mediated by the CEA family : basic and clinical perspectives
1989) The “initiator” as a transcription control element. Cell, 57, 103–113. , Markussen, G. and Thorsby, E. (1987) Interferonγ enhances expression of secretory component, the epithelial receptor for polymeric immunoglobulins. J. , 138, 4303–4306. , Szpirer, C. and Vassart, G. (1990) Structure, evolution and chromosomal localization of the human pregnancy-specific β1 glycoprotein gene family. Genomics, 6, 579–592. Svenberg, T. (1976) Carcinoembryonic antigen-like substances of human bile. Isolation and partial characterization.
Grunert, F. and Roos, D. (1992) CD66 nonspecific cross-reacting antigens are involved in neurophil adherence to cytokine-activated endothelial cells. J. Cell Biology, 118, 457–466. , Nakazato, H. and Matsuoka, Y. (1991) Molecular cloning of nonspecific cross-reacting antigens in human granulocytes. J. Biol. , 266, 11180–11817. , Kinugasa, T. and Matsuoka, Y. (1992) Three different NCA species, CGM6/CD67, NCA95 and NCA90 are comprised in the major 90 to 100 kDa band of granulocyte NCA detectable upon SDS-polyacrylamide gel electrophoresis .
E. and Yachi, A. (1990) Transcription of biliary glycoprotein I in malignant and nonmalignant human liver tissues. Int. Cancer, 45, 875–878. , Nakazato, H. C. 2. Cytogenet. , 52, 28–31. , Yuan, S-Y. and Shirota, K. (1993) Transcription of carcinoembryonic antigen in normal colon and colon carcinoma. Am. J. of Pathology, 143, 250–257. J. R. (1987) Carcinoembryonic antigen family: Expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage λgt11. Proc. Natl. Acad.