Apoptosis In Normal Development And Cancer by M Sluyser

By M Sluyser

In apoptosis within the mammalian method, cells have a finite lifestyles - they strengthen, are used after which die. melanoma cells get away this programmed regimen yet, from an figuring out of apoptosis, they are often programmed to die. This booklet addresses the

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Cytochem. 28, 670–676. 32 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 APOPTOSIS IN NORMAL DEVELOPMENT AND CANCER . , CHAUDUN, E. & COURTOIS, Y. (1985) Nuclear ADP-ribosylation in the chick lens during embryonic development. Biochem. Biophys. Res. Commun. 126, 859–866. F. A. (1990) Hypersensitivity to clinically useful alkylating agents and radiation in poly (ADP-ribose) polymerase-deficient cell lines. Cancer Commun. 2, 401–407. L. M. (1992) Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

Antibodies against Fas/APO-1 or its ligand induce apoptosis in immature T lymphocytes and cells expressing Fas/APO-1. The endogenous Fas/APO-1 ligand and its gene have recently been identified [72, 73]. A genetic deficiency of the lpr gene causes lymphoproliferation and an autoimmune disease that resembles systemic lupus erythematosus (SLE). The lpr gene has recently be shown to encode Fas/APO-1 [74]. Mutation of Fas/APO-1 does not result in deletion of autoreactive lymphocytes in mice. However, patients with SLE do not have mutations in the region homologus to the lpr gene.

1989) Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action. FEBS Lett. 245, 150–154. THOMAZY, V. & FESUS, L. (1989) Differential expression of tissue transglutaminase in human cells. Cell Tissue Res. 255, 215–224. C. & GRIFFIN, M. (1991) Apoptosis: a potential role for cytosolic transglutaminase and its importance in tumour progression. Biochim. Biophys. Acta 1096, 312–318. , PIREDDA, L. & FESUS, L. (1991) ‘Tissue’ transglutaminase is specifically expressed in neonatal rat liver cells undergoing apoptosis upon epidermal growth factor stimulation.

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