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Fluconazole 400mg daily for 14 days. Page 52 Ch apte r 1 0 : Ce n tr al N e r v o u s S y s te m I n fe c ti o n s A c u te B a c te r i a l M e n i n g i ti s Meningitis may be fulminant. The aetiology is established by examination of cerebrospinal fluid (CSF) obtained by lumbar puncture and sometimes by blood culture. When such specimens cannot be collected (obtained) immediately, empiric treatment should be started without delay. The standard recommendations for the empiric treatment of bacterial meningitis have undergone some significant changes in the last decade.
The recommended chemoprophylactic agents include: Rifampicin 20 mg/kg (to a maximum of 600 mg) given 12 hourly PO x 4 doses OR Ceftriaxone 250 mg (in adults) or 125 mg (in children) IM as a single dose OR Ciprofloxacin 500 mg PO as a single dose in adults and older children Page 45 I n fl u e n z a A Amantadine is effective against influenza A but not against influenza B. g. elderly persons, health-care providers, and those with chronic disease. It provides temporary protection for those at immediate risk, until immunisation has stimulated immunity 2 weeks after immunisation.
3. ORTHOPAEDIC SURGERY Arthroplasty of joints, and/or joint replacement. 1st generation cephalosporins eg. cefazolin 1 - 2 g pre-operatively. If the operation is longer than 3 hours, give a second dose. g. cefazolin 1 - 2 g 8 hrly). Open reduction of fracture 1st generation cephalosporin eg. cefazolin 1 - 2 g IV pre-op. Laminectomy, spinal fusion Prophylactic antibiotics have not been proved to be beneficial. Lower limb amputation 1st generation cephalosporins eg. cefazolin 1 - 2 g IV. OR cefoxitin 2 g IV.