Aging Phenomena: Relationships among Different Levels of by A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki,

By A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki, Takashi Makinodan, Lynn S. Baker (eds.)

The challenge of senescence, as mirrored within the historical past of reli­ gion and philosophy, has lengthy been one of many maximum issues of humankind. against this, gerontology as a department of technological know-how remains to be relatively younger. in the past decade, concomitant with fast development in our figuring out of the fundamental existence sciences, sizeable shops of information approximately organic getting older were gathered. this information, notwithstanding, bobbing up from many medical disciplines and occupied with various degrees of biologic association, turns out virtually random and covers every little thing from molecules to human societies. Theories complex to interpret the evidence and to appreciate the mech­ anisms interested by senescence have remained in person, instead of normal, territories. It has lengthy been felt by means of a few gerontologists that it used to be time for a number of the experts to step again and take a generalist view of gerontology, to re-examine and reevaluate the end result in their analyt­ ical goals at diversified degrees inside of a broader context. a few others might imagine it nonetheless untimely. It appeared, in spite of the fact that, that almost all of these who accumulated in Tokyo at the get together of the XIth foreign Congress of Gerontology have been of the opinion that there has been a lot to be received in searching for interrelationships one of the proof and theories originated within the diversified degrees of investiga­ tion in an try to discover and take pleasure in the organic drama of senescence as an entity.

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Three strains of human embryo lung fibroblasts (WI-38, IHR-90, and TIG-1) showed a linear increase in hemadsorption per mg protein of fibroblast as a function of population doubling level 20 CHARACTERIZATION OF AGING HUMAN FIBROBLASTS (",) 30 25 / ,-" \,. / : I: : 10 \ \ : : 15 OL OS If, \ \ .. I J \ ~ \ '. \ , '. ---.... ' \ \ • b. , \ " " ,\ 5 ' . --------~ ""... , /' ........... ~.. 1 pm) Fig. 13. Length of the short axis of ER of fractionated cells. Ordinate: percentage of cells with a given ER short axis from the total number of cells examined.

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