Acetylsalicylic Acid by Karsten Schrör

By Karsten Schrör

Written via a number one specialist on Aspirin-related examine, this can be the main finished treatise at the pharmacological results and medical purposes of 1 of the main winning medicines ever.
The textual content is written with a large viewers in brain, and to be effectively comprehensible for clinicians, pharmacists, biomedical researchers and pharmacologists alike.
This moment, thoroughly revised variation includes the most recent result of scientific and pharmacological examine on Acetylsalicylic acid, addressing the a number of pharmacological homes of this recognized drug with a balanced view on their translation into scientific perform, together with prevention from cardiovascular ailments and colorectal cancer.

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This explained the analgesic/anti-inflammatory properties of aspirin and other salicylates, which according to the current knowledge, are probably due to the inhibition of COX-2. Interestingly, acetylation of salicylates added a control of gene expression and function appears to be pharmacologically much more attractive – and efficient – than just the inhibition of activity of selected enzymes. Salicylates in plants are transcriptionally regulated “resistance genes” and form an essential part of cellular defense mechanisms.

Clinical Chemistry, 36, 131–135. G. C. (1992) Simultaneous determination of acetylsalicylic acid and its major metabolites in human serum by secondderivative synchronous fluorescence spectrometry. Analyst, 117, 877–882. 3 Aspirin and Malignancies j35 2 Pharmacology The pharmacology of aspirin is unique and characterized by the action of two compounds as parts of the same molecule: reactive acetate and salicylic acid (salicylate). In addition, unmetabolized aspirin itself has biological activities similar to salicylate on many cellular targets.

Quantification is done by measuring light absorbance at this wavelength by a spectrophotometer. TheTrindermethod issimple,inexpensive, rapid, and very reliable. Spectrophotometry lowers the detection limit to about 100 mg/ml. This is sufficient for therapeutic and toxic purposes. However, the Trinder method measures salicylate rather than ASA. (False) Positive results may be obtained with salicylamide or methylsalicylate. Conversely, the method can also be used to measure these compounds, for example, in the case of poisoning.

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