A Means to an End - The Biological Basis of Aging and Death by William R. Clark

By William R. Clark

Why will we age? Is getting older inevitable? Will advances in scientific wisdom let us expand the human lifespan past its current limits? simply because getting old has lengthy been the only irreducible truth of human lifestyles, those interesting questions come up extra usually within the context of technological know-how fiction than technology truth. yet contemporary discoveries within the fields of mobile biology and molecular genetics are heavily difficult the belief that human lifespans are past our regulate. With such discoveries in brain, famous phone biologist William R. Clark sincerely and elegantly describes how senescence starts off on the point of person cells and the way mobile replication could be sure up with getting older of the full organism. He explores the evolutionary starting place and serve as of getting older, the mobile connections among getting older and melanoma, the parallels among mobile senescence and Alzheimer's sickness, and the insights received via learning human genetic disorders--such as Werner's syndrome--that mimic the indications of getting older. Clark additionally explains how relief in caloric consumption may very well support raise lifespan, and the way the damaging results of oxidative parts within the physique can be restricted through the intake of antioxidants present in vegetables and fruit. In a last bankruptcy, Clark considers the social and fiscal elements of dwelling longer, the consequences of gene treatment on senescence, and what we would find out about getting older from experiments in cloning. it is a hugely readable, provocative account of a few of the main far-reaching and arguable questions we're prone to ask within the subsequent century.

Show description

Read or Download A Means to an End - The Biological Basis of Aging and Death PDF

Best cell biology books

Peptide Growth Factors Part B

The seriously acclaimed laboratory typical, equipment in Enzymology , is likely one of the such a lot hugely revered courses within the box of biochemistry. for the reason that 1955, each one quantity has been eagerly awaited, usually consulted, and praised by way of researchers and reviewers alike. The sequence includes a lot fabric nonetheless suitable this day - really a vital book for researchers in all fields of lifestyles sciences.

Liposomes, Part D

Liposomes are mobile constructions made of lipid molecules. very important as a mobile version within the learn of simple biology, liposomes also are utilized in scientific functions resembling drug supply and virus stories. Liposomes half D is a continuation of prior MIE Liposome volumes A, B, and C. Contents: Antibody or Ligand special Liposomes; setting delicate liposomes; liposomal oligonucleotides; liposomes in vivo

Isolation of Plant Organelles and Structures: Methods and Protocols

This e-book brings jointly the foremost concepts utilized in the isolation or enrichment of person populations of organelles and different subcellular buildings from vegetation with the aim that, by way of with the ability to isolate subcellular constructions, the examine and realizing of varied points of compartmentalized functionality in plant cells will be complex.

Additional info for A Means to an End - The Biological Basis of Aging and Death

Sample text

These are often thought of as accumulated biochemical "trash," but there is no real basis for such an assumption. One of the most common of these materials is something called lipofuscin, or "age pigment" because of its universal distribution in older people. ) Lipofuscin is found in intracellular granules, and in very old individuals these granules may appear to be crowding out cellular organelles and threatening their functional integrity. T h e major component of lipofuscin is fat, and in particular fat that has been oxidatively damaged.

S E N E S C E N C E . 2. 3 ter cases, and it is remarkably constant within a species even though only rarely, if ever, reached in the wild. On the other hand, maximum lifespan can be quite different between physically similar species living in the same ecological niche, and these differences are stably transmitted from one generation to the next. T h i s constancy and heritability of maximum lifespan within a species, and its independence of environmental factors—first recognized by Buffon in the eighteenth 15 A M E A N S TO AN END century—can be taken as a priori evidence that maximum lifespan is at least in part a genetically determined trait.

Despite a few claims to the contrary, there is ample evidence they do not die, at least not as an immediate consequence of the loss of the ability to divide. They simply lie idly in their culture dishes, continuing to make R N A and proteins, responding to many signals from the outside with an appropriate response—except for signals to begin replicating. At this stage they are behaving pretty much like cells removed from older people in terms of what they can and cannot do. It seems unlikely that cells that age naturally in culture and enter senescence are truly immortal, but unfortunately no one has yet followed them out in time to see whether and how they die.

Download PDF sample

Rated 4.49 of 5 – based on 14 votes