31st Hemophilia Symposium Hamburg 2000: Epidemiology by I. Scharrer (auth.), Professor Dr. med. Inge Scharrer,

By I. Scharrer (auth.), Professor Dr. med. Inge Scharrer, Professor Dr. med. Wolfgang Schramm (eds.)

Some 23. five% of all individuals and sufferers of therapy facilities accomplished the questionnaire. One outstanding truth is that participation was once optimum among aged sufferers with serious hemophilia, while in basic terms 12. 2% of family spoke back. overview of the implications published that most of individuals desire deal with­ ment in a hemophilia therapy heart with a excessive acceptance, while simply 2. 7% contemplate remedy in a really expert perform to be enough. the explanations for which are the need of the 24-h-availability of a doctor, typical certified exam of joints and muscle mass, documentation of product batches, laboratory assessments and reliable cooperation with different colleges. As many as sixty eight. nine% of the sufferers occasionally trip greater than 2 hundred km. What definitely performs a task this is belief within the remedy middle and its physicians, for it really is obvious that without reference to the truth that seventy four. three% re­ quested standardized remedy regimens for all remedy facilities, merely approximately 20% might swap to a closer middle. therapy with issue concentrates is usually thought of to be very secure. that's to assert, fifty eight. 1 % regard recombinant items to be very secure, while basically 24. three% suppose this for plasma items. in comparison, there have been often no significant modifications saw concerning consequence (factor intake, period of deal with­ ment). raise in greatest garage temperature (47. 2%) and half-life (73%) have been the main widespread solutions to the query of what positive aspects the goods should still have.

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Extra resources for 31st Hemophilia Symposium Hamburg 2000: Epidemiology Inhibitors in Hemophilia Therapy and Monitoring of Bleeds in Acute and Intensive Care Medicine Pediatric Hemostaseology Case Reports

Example text

In vitro experiments 36 A. Kallas et al. showed lower neutralization of FVIII concentrate containing vWF by FVIII antibodies of the studied patient and predicted a beneficial outcome using the same concentrate for immune tolerance therapy. The ITT effectively suppressed the production of inhibitory antibodies reacting mainly with FVIII light chain to a nondetectable level. FVIII antibodies of IgG4 subtype dominated over all other subtypes, except IgG 1 subtype at two different time points, where the higher level of IgG 1 was probably caused by the increased dosage of administered FVIII.

Bovine serum albumin (BSA) and pNPP (p-nitrophenylphosphate) were purchased from Sigma. Other chemicals were of analytical grade. 6). 28 A. Kallas et al. Methods FVIII antibodies in plasma samples taken during IT therapy were measured by Bethesda assay and by an ELISA method. Recombinant FVIII (Recombinate) was used as a coating agent for microplates. Neutralization of FVIII:C Activity in the Presence and Absence of vWF Plasma-derived FVIII-vWF concentrate (Haemoctin SDH) and recombinant FVIII (Recombinate) were diluted to 1 IU/ml of FVIII:C with TBS buffer containing 1% BSA and incubated with an equal volume of serially diluted (1:2 to 1:1000 in TBS-BSA) FVIII antibody plasma sample for 1 h at 37°C.

Changes in Epitope Specificity and in Distribution of IgG Subtypes 29 Distribution Antibodies Neutralized by FVIII Light Chain and Heavy Chain Measured by Chromogenic Method The plasma samples were diluted to neutralization activity of 4 BU/ml, except plasma samples, which contained::::: 4 BUIml of FVIII antibodies and were used undiluted, and incubated with an equal volume of serially diluted recombinant FVIII fragments as described in the previous assay. An aliquot was removed for measuring FVIII antibodies by an ELISA assay.

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